Endocrine Abstracts

Metabolic syndrome is an important social problem concerning a growing number of people. In different countries across Europe, its incidence is estimated at 17.4–28%. The metabolic syndrome is a constellation of risk factors for cardiovascular diseases. Hipothyreosis can additionally influence on lipid and carbohydrate disorders.The described study was a prospective, two-centre (A. Jurasz University Hospital No. 1 in Bydgoszcz, District Hospital in ...

Introduction: Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and HMG-CoA hepatic reductase, indirectly regulating the body’s lipid metabolism. This mechanism is already known, however the principles of regulating lipid metabolism through thyroid metabolism constitute an important and a desirable element of scientific research in thyreology. Thyrotropic hormone (TSH), triiodothyronine (fT3) and thyroxine (fT4) affect adipocytes and...

One of the important proangiogenic factors involved in the growth of normal and neoplastic tissues is vascular endothelial growth factor VEGF.Therefore we hypothesized, that serum VEGF concentration would differ between patients with metastatic and non-metastatic thyroid cancer, with multinodular goiter and healthy subjects. We also hypothesized that endogenous TSH stimulation would effect serum VEGF level. The study protocol was approved by the Ethical ...

The aim of the study was to estimate the influence of a thyroid remnants’ volume, postsurgical concentration of thyroglobulin and radioiodine dose on the early treatment efficacy of well differentiated thyroid cancer.Material and methods: We retrospectively analyzed 91 patients (76 females, 15 men) with well differentiated thyroid cancer.Results: Histological classification revealed 68.1% (62/91) papillary thyroid cancers, 25....

Tumor growth is limited by its neoangiogenesis, which is dependent on dynamic balance beetween it’s activators and inhibitors. One of the most important antiangiogenic factor is endostatin. Therefore we hypothesized, that serum endostatin concentration would differ between patients with metastatic and non-metastatic thyroid cancer, with multinodular goiter and healthy subjects. We also hypothesized that endogenous TSH stimulation would effect serum endostatin level.<p...

Introduction: Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a common condition of the nervous system. It causes an overwhelming, irresistible urge to move the legs, mainly in the evening and night hours. It occurs in 7.2–10.0% of the population of western countries. Etiopathogenesis of RLS is not fully understood, but there is a hypothesis than an important role may play the imbalance between thyroid function and the dopaminergic system. The main ai...

Introduction: Thyroid dysfunction affect up to 5% of pregnant women and hypothyroidism complicates up to 3% of pregnancies, of which 0.3–0.5% is diagnosed as overt, 2.0–2.5% as subclinical hypothyroidism. Obesity in pregnant women may further contribute to the development of hypothyroidism and adversely affect the pregnancy. The aim of the study was to assess the risk of hypothyroidism in overweight and obese pregnant women on the basis of concentrations of TSH, free...

The diagnosis of subclinical hypercortisolemia in patients with incidental adrenal tumors remains a challenge, as there are no unambiguous criteria for diagnosis. The discovery of a substance whose secretion increases under the influence of cortisol would make it easier to make therapeutic decisions. Hypercortisolism causes a change in the distribution of adipose tissue, so it can be assumed that it also affects secretion of proteins secreted by adipocytes (adipokines). The ai...

Introduction: In everyday practice, doctors often have to deal with patients who show features of depression - it has been proven that in 20–30% of cases it may be related to the ocurrence of another disease, such as hypothyroidism.Aim of study: The aim of the study was to verify the frequency of occurrence features of depression (based on Beck’s scale) in the population of patients with hypothyroidism and comparison to the general population.<...

Differentiated thyroid cancer (DTC) is a relatively mild disease if detected early.The aim of the study was ultrasound evaluation of thyroid gland, selection of thyroid nodules with high chances of malignancy, and their verification in fine-needle aspiration (FNA), as well as assessment of TSH concentration and antiTPO titre.The study involved 100 patients. DTC was diagnosed in 14 patients and undifferentiated or medullary thyroid ...